Book Review: Amebiasis. Biology and Pathogenesis of Entamoeba

Book Review: Amebiasis. Biology and Pathogenesis of Entamoeba

In every research laboratory there is " the book " —the standard text, given to people newly entering the field and frequently referred to by the rest of us. In the amoebiasis world, this was the massive and magisterial 1988 volume edited by Jonathan Ravdin. But since then there has not been a comparable work produced which would reflect the enormous increase in knowledge which has accrued in t...

Cysteine proteinases and the pathogenesis of amebiasis.

Amebiasis is a major cause of morbidity and mortality throughout the tropical world. Entamoeba histolytica is now recognized as a separate species from the morphologically identical E. dispar, which cannot invade. Cysteine proteinases are a key virulence factor of E. histolytica and play a role in intestinal invasion by degrading the extracellular matrix and circumventing the host immune respon...

Immune Response of Amebiasis and Immune Evasion by Entamoeba histolytica

Entamoeba histolytica is a protozoan parasite and the causative agent of amebiasis. It is estimated approximately 1% of humans are infected with E. histolytica, resulting in an estimate of 100,000 deaths annually. Clinical manifestations of amebic infection range widely from asymptomatic to severe symptoms, including dysentery and extra-intestinal abscesses. Like other infectious diseases, it i...

Entamoeba histolytica infection in children and protection from subsequent amebiasis.

The contribution of amebiasis to the burden of diarrheal disease in children and the degree to which immunity is acquired from natural infection were assessed in a 4-year prospective observational study of 289 preschool children in an urban slum in Dhaka, Bangladesh. Entamoeba histolytica infection was detected at least once in 80%, and repeat infection in 53%, of the children who completed 4 y...

Book Review: Systems and Synthetic Biology